Influenza immunization in immunosuppressed children
Identifieur interne : 002A16 ( Main/Exploration ); précédent : 002A15; suivant : 002A17Influenza immunization in immunosuppressed children
Auteurs : Peter A. Gross [États-Unis] ; Hahng Lee [États-Unis] ; James A. Wolff [États-Unis] ; Caroline Breese Hall [États-Unis] ; Anthony B. Minnefore [États-Unis] ; Mabel E. Lazicki [États-Unis]Source :
- The Journal of Pediatrics [ 0022-3476 ] ; 1978.
English descriptors
- Teeft :
- Acute leukemia, Antibody response, Bivalent influenza vaccine, Blood cell count, Blood counts, Chemotherapy, Chemotherapy prevaccination postvaccination, Cumulative lymphocyte count, Current study, Geographic differences, Granulocyte count, Hemagglutination inhibition, Hematologic malignancies, Immune, Immune response, Immune responses, Immunization, Immunize children, Immunosuppressed children, Influenza, Influenza immunization, Influenza vaccine, Malignancy, National trials, Normal individuals, Optimum time, Pediatrics january, Postvaccination, Protective levels, Reaction index, Recent chemotherapy, Seroconversion, Seroconversion rate, Serologic data, Significant differences, Similar observations, Solid tumors, Strong memorial hospital, Titer, Vaccination, Vaccine, Vaccine antigen chemotherapy, Vaccine recipients, Whole virus vaccine, Whole virus vaccines, York city.
Abstract
Optimal influenza immunization of individuals with malignancy and other immunodeficient states requires an understanding of responses to currently recommended regimens. Children with acute lymphocytic leukemia and other malignancies between three and 17 years of age were immunized with bivalent influenza vaccine containing A/New Jersey/76 and A/Victoria/75. Following a two-dose immunization schedule, only 37% (25/68) on cancer chemotherapy seroconverted to a hemagglutination inhibition titer ≥20 for A/NJ/76; the seroconversion rate in those not on chemotherapy was 92% (68/74, P<0.001). The immune response to the A/Vic/75 antigen was also related to a history of recent chemotherapy. There was no correlation between the immune response and the peripheral white blood cell count except at counts ≤1,000. The optimum time to immunize children with malignancies is when they have been off chemotherapy for one month and have peripheral white blood counts greater than 1,000.
Url:
DOI: 10.1016/S0022-3476(78)80065-1
Affiliations:
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Children with acute lymphocytic leukemia and other malignancies between three and 17 years of age were immunized with bivalent influenza vaccine containing A/New Jersey/76 and A/Victoria/75. Following a two-dose immunization schedule, only 37% (25/68) on cancer chemotherapy seroconverted to a hemagglutination inhibition titer ≥20 for A/NJ/76; the seroconversion rate in those not on chemotherapy was 92% (68/74, P<0.001). The immune response to the A/Vic/75 antigen was also related to a history of recent chemotherapy. There was no correlation between the immune response and the peripheral white blood cell count except at counts ≤1,000. The optimum time to immunize children with malignancies is when they have been off chemotherapy for one month and have peripheral white blood counts greater than 1,000.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>New Jersey</li><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Gross, Peter A" sort="Gross, Peter A" uniqKey="Gross P" first="Peter A." last="Gross">Peter A. Gross</name></noRegion><name sortKey="Gross, Peter A" sort="Gross, Peter A" uniqKey="Gross P" first="Peter A." last="Gross">Peter A. Gross</name><name sortKey="Gross, Peter A" sort="Gross, Peter A" uniqKey="Gross P" first="Peter A." last="Gross">Peter A. Gross</name><name sortKey="Hall, Caroline Breese" sort="Hall, Caroline Breese" uniqKey="Hall C" first="Caroline Breese" last="Hall">Caroline Breese Hall</name><name sortKey="Lazicki, Mabel E" sort="Lazicki, Mabel E" uniqKey="Lazicki M" first="Mabel E." last="Lazicki">Mabel E. Lazicki</name><name sortKey="Lazicki, Mabel E" sort="Lazicki, Mabel E" uniqKey="Lazicki M" first="Mabel E." last="Lazicki">Mabel E. Lazicki</name><name sortKey="Lee, Hahng" sort="Lee, Hahng" uniqKey="Lee H" first="Hahng" last="Lee">Hahng Lee</name><name sortKey="Minnefore, Anthony B" sort="Minnefore, Anthony B" uniqKey="Minnefore A" first="Anthony B." last="Minnefore">Anthony B. Minnefore</name><name sortKey="Wolff, James A" sort="Wolff, James A" uniqKey="Wolff J" first="James A." last="Wolff">James A. Wolff</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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